Toscana virus non-structural protein NSs acts as E3 ubiquitin ligase promoting RIG-I degradation

It is known that the non-structural protein (NSs) of Toscana virus (TOSV), an emergent sandfly-borne virus causing meningitis or more severe central nervous system injuries in humans, exerts its function triggering RIG-I for degradation in a proteasome-dependent manner, thus breaking off the IFN-β p...

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Vydáno v:PLoS Pathog
Hlavní autoři: Gori Savellini, Gianni, Anichini, Gabriele, Gandolfo, Claudia, Prathyumnan, Shibily, Cusi, Maria Grazia
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901176/
https://ncbi.nlm.nih.gov/pubmed/31815967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008186
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