Epithelial sodium channels in endothelial cells mediate diet-induced endothelium stiffness and impaired vascular relaxation in obese female mice

OBJECTIVE: Mineralocorticoid receptor activation of the epithelial sodium channel in endothelial cells (ECs) (EnNaC) is accompanied by aldosterone induced endothelial stiffening and impaired nitric oxide (NO)-mediated arterial relaxation. Recent data support enhanced activity of the alpha subunit of...

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Publicado en:Metabolism
Autores principales: Sowers, James R., Habibi, Javad, Aroor, Annayya R., Yang, Yan, Lastra, Guido, Hill, Michael A., Whaley-Connell, Adam, Jaisser, Frederic, Jia, Guanghong
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901094/
https://ncbi.nlm.nih.gov/pubmed/31302199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2019.153946
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