Identification of a T follicular helper cell subset that drives anaphylactic IgE

Cross-linking of high-affinity immunoglobulin E (IgE) results in the life-threatening allergic reaction, anaphylaxis. Yet the cellular mechanisms that induce B cells to produce IgE in response to allergens remain poorly understood. T follicular helper (Tfh) cells direct the affinity and isotype of a...

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Published in:Science
Main Authors: Gowthaman, Uthaman, Chen, Jennifer S., Zhang, Biyan, Flynn, William F., Lu, Yisi, Song, Wenzhi, Joseph, Julie, Gertie, Jake A., Xu, Lan, Collet, Magalie A., Grassmann, Jessica, Simoneau, Tregony, Chiang, David, Berin, M. Cecilia, Craft, Joseph E., Weinstein, Jason S., Williams, Adam, Eisenbarth, Stephanie C.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901029/
https://ncbi.nlm.nih.gov/pubmed/31371561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw6433
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