Identification of a T follicular helper cell subset that drives anaphylactic IgE

Cross-linking of high-affinity immunoglobulin E (IgE) results in the life-threatening allergic reaction, anaphylaxis. Yet the cellular mechanisms that induce B cells to produce IgE in response to allergens remain poorly understood. T follicular helper (Tfh) cells direct the affinity and isotype of a...

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Publicado no:Science
Main Authors: Gowthaman, Uthaman, Chen, Jennifer S., Zhang, Biyan, Flynn, William F., Lu, Yisi, Song, Wenzhi, Joseph, Julie, Gertie, Jake A., Xu, Lan, Collet, Magalie A., Grassmann, Jessica, Simoneau, Tregony, Chiang, David, Berin, M. Cecilia, Craft, Joseph E., Weinstein, Jason S., Williams, Adam, Eisenbarth, Stephanie C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901029/
https://ncbi.nlm.nih.gov/pubmed/31371561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw6433
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