Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy

Medulloblastoma (MB), the most frequent malignant childhood brain tumor, can arise from cellular malfunctions during hindbrain development. Here we generate humanized models for Sonic Hedgehog (SHH)-subgroup MB via MYCN overexpression in primary human hindbrain-derived neuroepithelial stem (hbNES) c...

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Publicat a:Cell Stem Cell
Autors principals: Čančer, Matko, Hutter, Sonja, Holmberg, Karl O., Rosén, Gabriela, Sundström, Anders, Tailor, Jignesh, Bergström, Tobias, Garancher, Alexandra, Essand, Magnus, Wechsler-Reya, Robert J., Falk, Anna, Weishaupt, Holger, Swartling, Fredrik J.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900751/
https://ncbi.nlm.nih.gov/pubmed/31786016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.10.005
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