Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria

Oligoribonucleases are conserved enzymes that degrade short RNA molecules of up to 5 nt in length and are assumed to constitute the final stage of RNA turnover. Here we demonstrate that REXO2 is a specialized dinucleotide-degrading enzyme that shows no preference between RNA and DNA dinucleotide sub...

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Udgivet i:Mol Cell
Main Authors: Nicholls, Thomas J., Spåhr, Henrik, Jiang, Shan, Siira, Stefan J., Koolmeister, Camilla, Sharma, Sushma, Kauppila, Johanna H.K., Jiang, Min, Kaever, Volkhard, Rackham, Oliver, Chabes, Andrei, Falkenberg, Maria, Filipovska, Aleksandra, Larsson, Nils-Göran, Gustafsson, Claes M.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900737/
https://ncbi.nlm.nih.gov/pubmed/31588022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.09.010
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