ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism

Inositol phosphates (IPs) comprise a network of phosphorylated molecules that play multiple signaling roles in eukaryotes. IPs synthesis is believed to originate with IP(3) generated from PIP(2) by phospholipase C (PLC). Here, we report that in mammalian cells PLC-generated IPs are rapidly recycled...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Desfougères, Yann, Wilson, Miranda S. C., Laha, Debabrata, Miller, Gregory J., Saiardi, Adolfo
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900528/
https://ncbi.nlm.nih.gov/pubmed/31754032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911431116
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