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A Fluorescent Activatable AND‐Gate Chemokine CCL2 Enables In Vivo Detection of Metastasis‐Associated Macrophages

We report the novel chemical design of fluorescent activatable chemokines as highly specific functional probes for imaging subpopulations of immune cells in live tumours. Activatable chemokines behave as AND‐gates since they emit only after receptor binding and intracellular activation, showing enha...

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Bibliografske podrobnosti
izdano v:Angew Chem Int Ed Engl
Main Authors: Fernandez, Antonio, Thompson, Emily J., Pollard, Jeffrey W., Kitamura, Takanori, Vendrell, Marc
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900180/
https://ncbi.nlm.nih.gov/pubmed/31535788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201910955
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