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Photochemical C−H Hydroxyalkylation of Quinolines and Isoquinolines

We report herein a visible light‐mediated C−H hydroxyalkylation of quinolines and isoquinolines that proceeds via a radical path. The process exploits the excited‐state reactivity of 4‐acyl‐1,4‐dihydropyridines, which can readily generate acyl radicals upon blue light absorption. By avoiding the nee...

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Publicat a:Angew Chem Int Ed Engl
Autors principals: Bieszczad, Bartosz, Perego, Luca Alessandro, Melchiorre, Paolo
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900123/
https://ncbi.nlm.nih.gov/pubmed/31529788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201910641
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