Enhancing Potency and Selectivity of a DC‐SIGN Glycomimetic Ligand by Fragment‐Based Design: Structural Basis

Chemical modification of pseudo‐dimannoside ligands guided by fragment‐based design allowed for the exploitation of an ammonium‐binding region in the vicinity of the mannose‐binding site of DC‐SIGN, leading to the synthesis of a glycomimetic antagonist (compound 16) of unprecedented affinity and sel...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Medve, Laura, Achilli, Silvia, Guzman‐Caldentey, Joan, Thépaut, Michel, Senaldi, Luca, Le Roy, Aline, Sattin, Sara, Ebel, Christine, Vivès, Corinne, Martin‐Santamaria, Sonsoles, Bernardi, Anna, Fieschi, Franck
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899773/
https://ncbi.nlm.nih.gov/pubmed/31469191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201903391
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