Helix N-Cap Residues Drive the Acid Unfolding That Is Essential in the Action of the Toxin Colicin A

[Image: see text] Numerous bacterial toxins and other virulence factors use low pH as a trigger to convert from water-soluble to membrane-inserted states. In the case of colicins, the pore-forming domain of colicin A (ColA-P) has been shown both to undergo a clear acidic unfolding transition and to...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Huang, Yan, Soliakov, Andrei, Le Brun, Anton P., Macdonald, Colin, Johnson, Christopher L., Solovyova, Alexandra S., Waller, Helen, Moore, Geoffrey R., Lakey, Jeremy H.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2019
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899464/
https://ncbi.nlm.nih.gov/pubmed/31686499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00705
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