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Synergistic Coordination of Chromatin Torsional Mechanics and Topoisomerase Activity
DNA replication in eukaryotes generates DNA supercoiling which may intertwine (braid) daughter chromatin fibers to form precatenanes, posing topological challenges during chromosome segregation. The mechanisms that limit precatenane formation remain unclear. By making direct torque measurements, we...
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| Publicado no: | Cell |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6899335/ https://ncbi.nlm.nih.gov/pubmed/31626768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.09.034 |
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