Aberrant mechanosensing in injured intervertebral discs as a result of boundary-constraint disruption and residual-strain loss

In fibrous tissues, pre-stressed boundary constraints at bone interfaces instil residual strain throughout the tissue, even when unloaded. For example, internal swelling pressures in the central nucleus pulposus of the intervertebral disc generate pre-strain in the outer annulus fibrosus. With injur...

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Veröffentlicht in:Nat Biomed Eng
Hauptverfasser: Bonnevie, Edward D., Gullbrand, Sarah E., Ashinsky, Beth G., Tsinman, Tonia K., Elliott, Dawn M., Chao, Pen-hsiu Grace, Smith, Harvey E., Mauck, Robert L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899202/
https://ncbi.nlm.nih.gov/pubmed/31611678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-019-0458-4
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