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Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody
The HIV-1 envelope (Env) glycoprotein, a (gp120-gp41)(3) trimer, mediates fusion of viral and host cell membranes after gp120 binding to host receptor CD4. Receptor binding triggers conformational changes allowing coreceptor (CCR5) recognition through CCR5’s tyrosine-sulfated N-terminus, release of...
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| Pubblicato in: | Nat Struct Mol Biol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6899201/ https://ncbi.nlm.nih.gov/pubmed/31792452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0344-5 |
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