Diabetes Mellitus Severity and a Switch From Using Lipoprotein Lipase to Adipose‐Derived Fatty Acid Results in a Cardiac Metabolic Signature That Embraces Cell Death

BACKGROUND: Fatty acid (FA) provision to the heart is from cardiomyocyte and adipose depots, plus lipoprotein lipase action. We tested how a graded reduction in insulin impacts the source of FA used by cardiomyocytes and the cardiac adaptations required to process these FA. METHODS AND RESULTS: Rats...

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Bibliographic Details
Published in:J Am Heart Assoc
Main Authors: Puri, Karanjit, Lal, Nathaniel, Shang, Rui, Ghosh, Sanjoy, Flibotte, Stephane, Dyer, Roger, Hussein, Bahira, Rodrigues, Brian
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898854/
https://ncbi.nlm.nih.gov/pubmed/31665961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.014022
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