Diabetes Mellitus Severity and a Switch From Using Lipoprotein Lipase to Adipose‐Derived Fatty Acid Results in a Cardiac Metabolic Signature That Embraces Cell Death

BACKGROUND: Fatty acid (FA) provision to the heart is from cardiomyocyte and adipose depots, plus lipoprotein lipase action. We tested how a graded reduction in insulin impacts the source of FA used by cardiomyocytes and the cardiac adaptations required to process these FA. METHODS AND RESULTS: Rats...

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Vydáno v:J Am Heart Assoc
Hlavní autoři: Puri, Karanjit, Lal, Nathaniel, Shang, Rui, Ghosh, Sanjoy, Flibotte, Stephane, Dyer, Roger, Hussein, Bahira, Rodrigues, Brian
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898854/
https://ncbi.nlm.nih.gov/pubmed/31665961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.014022
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