Antagonism of the Thromboxane‐Prostanoid Receptor as a Potential Therapy for Cardiomyopathy of Muscular Dystrophy

BACKGROUND: Muscular dystrophy (MD) causes a progressive cardiomyopathy characterized by diffuse fibrosis, arrhythmia, heart failure, and early death. Activation of the thromboxane‐prostanoid receptor (TPr) increases calcium transients in cardiomyocytes and is proarrhythmic and profibrotic. We hypot...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: West, James D., Galindo, Cristi L., Kim, Kyungsoo, Shin, John Jonghyun, Atkinson, James B., Macias‐Perez, Ines, Pavliv, Leo, Knollmann, Bjorn C., Soslow, Jonathan H., Markham, Larry W., Carrier, Erica J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898850/
https://ncbi.nlm.nih.gov/pubmed/31662020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.011902
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