Novel Screening Method Identifies PI3Kα, mTOR, and IGF1R as Key Kinases Regulating Cardiomyocyte Survival

BACKGROUND: Small molecule kinase inhibitors (KIs) are a class of agents currently used for treatment of various cancers. Unfortunately, treatment of cancer patients with some of the KIs is associated with cardiotoxicity, and there is an unmet need for methods to predict their cardiotoxicity. Here,...

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Bibliografiske detaljer
Udgivet i:J Am Heart Assoc
Main Authors: Elmadani, Manar, Khan, Suleiman, Tenhunen, Olli, Magga, Johanna, Aittokallio, Tero, Wennerberg, Krister, Kerkelä, Risto
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898841/
https://ncbi.nlm.nih.gov/pubmed/31617439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.013018
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