Cre-inducible Adeno Associated Virus-mediated Expression of P301L Mutant Tau Causes Motor Deficits and Neuronal Degeneration in the Substantia Nigra

Accumulation of microtubule associated protein tau in the substantia nigra is associated with several tauopathies including progressive supranuclear palsy (PSP). A number of studies have used mutant tau transgenic mouse model to mimic the neuropathology of tauopathies and disease phenotypes. However...

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Publicat a:Neuroscience
Autors principals: You, Yang, Botros, Mina B., Van Enoo, Alicia A., Bockmiller, Aaron, Herron, Shawn, Delpech, Jean Christophe, Ikezu, Tsuneya
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898791/
https://ncbi.nlm.nih.gov/pubmed/31689387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2019.10.001
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