Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

Increased glucose uptake and metabolism is a prominent phenotype of most cancers, but efforts to clinically target this metabolic alteration have been challenging. Here, we present evidence that lactoylglutathione (LGSH), a byproduct of methylglyoxal detoxification, is elevated in both human and mur...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Luengo, Alba, Abbott, Keene L., Davidson, Shawn M., Hosios, Aaron M., Faubert, Brandon, Chan, Sze Ham, Freinkman, Elizaveta, Zacharias, Lauren G., Mathews, Thomas P., Clish, Clary B., DeBerardinis, Ralph J., Lewis, Caroline A., Vander Heiden, Matthew G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898239/
https://ncbi.nlm.nih.gov/pubmed/31811141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13419-4
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