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A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity

Curative cancer therapies are uncommon and nearly always involve multi-drug combinations developed by experimentation in humans; unfortunately, the mechanistic basis for the success of such combinations has rarely been investigated in detail, obscuring lessons learned. Here, we use isobologram analy...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Palmer, Adam C, Chidley, Christopher, Sorger, Peter K
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6897534/
https://ncbi.nlm.nih.gov/pubmed/31742555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50036
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