In-situ vaccination using focused ultrasound heating and anti-CD-40 agonistic antibody enhances T-cell mediated local and abscopal effects in murine melanoma

The success of melanoma immunotherapy is dependent on the presence of activated and functional T-cells in tumors. The objective of this study was to investigate the impact of local-focused ultrasound (FUS) heating (~42–45°C) and in-situ anti-CD-40 agonistic antibody in enhancing T-cell function for...

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Veröffentlicht in:Int J Hyperthermia
Hauptverfasser: Singh, Mohit Pratap, Sethuraman, Sri Nandhini, Ritchey, Jerry, Fiering, Steven, Guha, Chandan, Malayer, Jerry, Ranjan, Ashish
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6897315/
https://ncbi.nlm.nih.gov/pubmed/31795832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/02656736.2019.1663280
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