Mycobacterium tuberculosis releases an antacid that remodels phagosomes

Mycobacterium tuberculosis (Mtb) is world’s most deadly pathogen. Unlike less virulent mycobacteria, Mtb produces 1-tuberculosinyladenosine (1-TbAd), an unusual terpene nucleoside of unknown function. Here we show that 1-TbAd is a naturally evolved phagolysosome disruptor. 1-TbAd is highly prevalent...

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Publicado no:Nat Chem Biol
Main Authors: Buter, Jeffrey, Cheng, Tan-Yun, Ghanem, Marwan, Grootemaat, Anita E., Raman, Sahadevan, Feng, Xinxin, Plantijn, Ashmir R., Ennis, Thomas, Wang, Joyce, Cotton, Rachel N., Layre, Emilie, Ramnarine, Alexandrea K., Mayfield, Jacob A., Young, David C., Martinot, Amanda Jezek, Siddiqi, Noman, Wakabayashi, Shoko, Botella, Helene, Calderon, Roger, Murray, Megan, Ehrt, Sabine, Snider, Barry B., Reed, Michael B., Oldfield, Eric, Tan, Shumin, Rubin, Eric J., Behr, Marcel A., van der Wel, Nicole N., Minnaard, Adriaan J., Moody, D. Branch
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896213/
https://ncbi.nlm.nih.gov/pubmed/31427817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0336-0
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