Coexisting Germline CHEK2 and Somatic BRAF(V600E) Mutations in Papillary Thyroid Cancer and Their Association with Clinicopathological Features and Disease Course

BRAF(V600E) is the most common somatic mutation in papillary thyroid carcinoma (PTC) and the majority of evidence indicates that it is associated with an aggressive clinical course. Germline mutations of the CHEK2 gene impair the DNA damage repair process and increase the risk of PTC. Coexistence of...

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Bibliographic Details
Published in:Cancers (Basel)
Main Authors: Gąsior-Perczak, Danuta, Kowalik, Artur, Walczyk, Agnieszka, Siołek, Monika, Gruszczyński, Krzysztof, Pałyga, Iwona, Mikina, Estera, Trybek, Tomasz, Kopczyński, Janusz, Mężyk, Ryszard, Góźdź, Stanisław, Kowalska, Aldona
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896084/
https://ncbi.nlm.nih.gov/pubmed/31703344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11111744
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