Coexisting Germline CHEK2 and Somatic BRAF(V600E) Mutations in Papillary Thyroid Cancer and Their Association with Clinicopathological Features and Disease Course

BRAF(V600E) is the most common somatic mutation in papillary thyroid carcinoma (PTC) and the majority of evidence indicates that it is associated with an aggressive clinical course. Germline mutations of the CHEK2 gene impair the DNA damage repair process and increase the risk of PTC. Coexistence of...

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Publicado no:Cancers (Basel)
Main Authors: Gąsior-Perczak, Danuta, Kowalik, Artur, Walczyk, Agnieszka, Siołek, Monika, Gruszczyński, Krzysztof, Pałyga, Iwona, Mikina, Estera, Trybek, Tomasz, Kopczyński, Janusz, Mężyk, Ryszard, Góźdź, Stanisław, Kowalska, Aldona
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896084/
https://ncbi.nlm.nih.gov/pubmed/31703344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11111744
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