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Evolutionary coupling analysis identifies the impact of disease-associated variants at less-conserved sites
Genome-wide association studies have discovered a large number of genetic variants in human patients with the disease. Thus, predicting the impact of these variants is important for sorting disease-associated variants (DVs) from neutral variants. Current methods to predict the mutational impacts dep...
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| Publicado en: | Nucleic Acids Res |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6895274/ https://ncbi.nlm.nih.gov/pubmed/31199866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz536 |
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