Cockayne syndrome group B deficiency reduces H3K9me3 chromatin remodeler SETDB1 and exacerbates cellular aging

Cockayne syndrome is an accelerated aging disorder, caused by mutations in the CSA or CSB genes. In CSB-deficient cells, poly (ADP ribose) polymerase (PARP) is persistently activated by unrepaired DNA damage and consumes and depletes cellular nicotinamide adenine dinucleotide, which leads to mitocho...

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Publicat a:Nucleic Acids Res
Autors principals: Lee, Jong-Hyuk, Demarest, Tyler G, Babbar, Mansi, Kim, Edward W, Okur, Mustafa N, De, Supriyo, Croteau, Deborah L, Bohr, Vilhelm A
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895253/
https://ncbi.nlm.nih.gov/pubmed/31276581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz568
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