Molecular insight into RNA polymerase I promoter recognition and promoter melting

RNA polymerase I (Pol I) assembles with core factor (CF) and Rrn3 on the rDNA core promoter for transcription initiation. Here, we report cryo-EM structures of closed, intermediate and open Pol I initiation complexes from 2.7 to 3.7 Å resolution to visualize Pol I promoter melting and to structurall...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Sadian, Yashar, Baudin, Florence, Tafur, Lucas, Murciano, Brice, Wetzel, Rene, Weis, Felix, Müller, Christoph W.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895186/
https://ncbi.nlm.nih.gov/pubmed/31804486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13510-w
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