Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

African trypanosomiasis is a disease caused by Trypanosoma brucei parasites with limited treatment options. Trypanosoma is unable to synthesize purines de novo and relies solely on their uptake and interconversion from the host, constituting purine nucleoside analogues a potential source of antitryp...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hulpia, Fabian, Mabille, Dorien, Campagnaro, Gustavo D., Schumann, Gabriela, Maes, Louis, Roditi, Isabel, Hofer, Anders, de Koning, Harry P., Caljon, Guy, Van Calenbergh, Serge
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895180/
https://ncbi.nlm.nih.gov/pubmed/31804484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13522-6
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