Common genetic variants associated with Parkinson’s disease display widespread signature of epigenetic plasticity

Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of α-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost 100 sequence variants linked to PD in SNCA. However, the consequences of t...

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Vydáno v:Sci Rep
Hlavní autoři: Sharma, Amit, Osato, Naoki, Liu, Hongde, Asthana, Shailendra, Dakal, Tikam Chand, Ambrosini, Giovanna, Bucher, Philipp, Schmitt, Ina, Wüllner, Ullrich
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895091/
https://ncbi.nlm.nih.gov/pubmed/31804560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54865-w
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