Genomic Profile and BRCA-1 Promoter Methylation Status in BRCA Mutated Ovarian Cancer: New Insights in Predictive Biomarkers of Olaparib Response

Objective: We assessed the genomic profile of four representative BRCA-mutated ovarian cancer (OC) patients treated with olaparib to investigate the relationship between intratumor heterogeneity and response to olaparib treatment. The main aim is to identify possible predictive biomarkers of respons...

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Detalhes bibliográficos
Publicado no:Front Oncol
Principais autores: Franzese, Elisena, Centonze, Sara, Diana, Anna, Lombardi, Angela, Carlino, Francesca, Guerrera, Luigi Pio, De Vita, Ferdinando, Caraglia, Michele, Pignata, Sandro, Ciardiello, Fortunato, Orditura, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895028/
https://ncbi.nlm.nih.gov/pubmed/31850198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01289
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