Genomic Profile and BRCA-1 Promoter Methylation Status in BRCA Mutated Ovarian Cancer: New Insights in Predictive Biomarkers of Olaparib Response

Objective: We assessed the genomic profile of four representative BRCA-mutated ovarian cancer (OC) patients treated with olaparib to investigate the relationship between intratumor heterogeneity and response to olaparib treatment. The main aim is to identify possible predictive biomarkers of respons...

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Bibliografiska uppgifter
I publikationen:Front Oncol
Huvudupphovsmän: Franzese, Elisena, Centonze, Sara, Diana, Anna, Lombardi, Angela, Carlino, Francesca, Guerrera, Luigi Pio, De Vita, Ferdinando, Caraglia, Michele, Pignata, Sandro, Ciardiello, Fortunato, Orditura, Michele
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2019
Ämnen:
Oncology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895028/
https://ncbi.nlm.nih.gov/pubmed/31850198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01289
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