Genomic Profile and BRCA-1 Promoter Methylation Status in BRCA Mutated Ovarian Cancer: New Insights in Predictive Biomarkers of Olaparib Response

Objective: We assessed the genomic profile of four representative BRCA-mutated ovarian cancer (OC) patients treated with olaparib to investigate the relationship between intratumor heterogeneity and response to olaparib treatment. The main aim is to identify possible predictive biomarkers of respons...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Oncol
Egile Nagusiak: Franzese, Elisena, Centonze, Sara, Diana, Anna, Lombardi, Angela, Carlino, Francesca, Guerrera, Luigi Pio, De Vita, Ferdinando, Caraglia, Michele, Pignata, Sandro, Ciardiello, Fortunato, Orditura, Michele
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2019
Gaiak:
Oncology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895028/
https://ncbi.nlm.nih.gov/pubmed/31850198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01289
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