Genomic Profile and BRCA-1 Promoter Methylation Status in BRCA Mutated Ovarian Cancer: New Insights in Predictive Biomarkers of Olaparib Response

Objective: We assessed the genomic profile of four representative BRCA-mutated ovarian cancer (OC) patients treated with olaparib to investigate the relationship between intratumor heterogeneity and response to olaparib treatment. The main aim is to identify possible predictive biomarkers of respons...

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Foilsithe in:Front Oncol
Main Authors: Franzese, Elisena, Centonze, Sara, Diana, Anna, Lombardi, Angela, Carlino, Francesca, Guerrera, Luigi Pio, De Vita, Ferdinando, Caraglia, Michele, Pignata, Sandro, Ciardiello, Fortunato, Orditura, Michele
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2019
Ábhair:
Oncology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895028/
https://ncbi.nlm.nih.gov/pubmed/31850198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01289
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