In Vivo Synaptic Density Imaging with (11)C-UCB-J Detects Treatment Effects of Saracatinib in a Mouse Model of Alzheimer Disease

(11)C-UCB-J is a new PET tracer for synaptic density imaging. Recently, we conducted (11)C-UCB-J PET on patients with mild cognitive impairment or early Alzheimer disease (AD) and found a 41% decrease in specific binding in the hippocampus compared with healthy subjects. We hypothesized that (11)C-U...

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Vydáno v:J Nucl Med
Hlavní autoři: Toyonaga, Takuya, Smith, Levi M., Finnema, Sjoerd J., Gallezot, Jean-Dominique, Naganawa, Mika, Bini, Jason, Mulnix, Tim, Cai, Zhengxin, Ropchan, Jim, Huang, Yiyun, Strittmatter, Stephen M., Carson, Richard E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society of Nuclear Medicine 2019
Témata:
Neurology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894376/
https://ncbi.nlm.nih.gov/pubmed/31101744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.118.223867
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