Shisa3 brakes resistance to EGFR-TKIs in lung adenocarcinoma by suppressing cancer stem cell properties

BACKGROUND: Although EGFR tyrosine kinase inhibitors (EGFR-TKIs) are beneficial to lung adenocarcinoma patients with sensitive EGFR mutations, resistance to these inhibitors induces a cancer stem cell (CSC) phenotype. Here, we clarify the function and molecular mechanism of shisa3 as a suppressor th...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Si, Jiahui, Ma, Yuanyuan, Bi, Ji Wang, Xiong, Ying, Lv, Chao, Li, Shaolei, Wu, Nan, Yang, Yue
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894286/
https://ncbi.nlm.nih.gov/pubmed/31801598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1486-3
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