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mTORC1 as a cell-intrinsic rheostat that shapes development, preimmune repertoire, and function of B lymphocytes

Ample evidence indicates that nutrient concentrations in extracellular milieux affect signaling mediated by environmental sensor proteins. For instance, the mechanistic target of rapamycin (mTOR) is reduced during protein malnutrition and is known to be modulated by concentrations of several amino a...

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Detalles Bibliográficos
Publicado en:FASEB J
Autores principales: Raybuck, Ariel L., Lee, Keunwook, Cho, Sung Hoon, Li, Jingxin, Thomas, James W., Boothby, Mark R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894075/
https://ncbi.nlm.nih.gov/pubmed/31533002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900069R
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