Placental growth factor negatively regulates retinal endothelial cell barrier function through suppression of glucose-6-phosphate dehydrogenase and antioxidant defense systems

We report that placental growth factor (PlGF) negatively affects the endothelial cell (EC) barrier function through a novel regulatory mechanism. The PlGF mAb promotes (but recombinant protein disrupts) EC barrier function, thus affecting the barrier-forming protein levels, membrane distribution, an...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Huang, Hu, Lennikov, Anton, Saddala, Madhu Sudhana, Gozal, David, Grab, Dennis J., Khalyfa, Abdelnaby, Fan, Lijuan
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894064/
https://ncbi.nlm.nih.gov/pubmed/31585507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201901353R
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