Endothelial cell-specific redox gene modulation inhibits angiogenesis but promotes B16F0 tumor growth in mice

Glutaredoxin-1 (Glrx) is a small cytosolic enzyme that removes S-glutathionylation, glutathione adducts of protein cysteine residues, thus modulating redox signaling and gene transcription. Although Glrx up-regulation prevented endothelial cell (EC) migration and global Glrx transgenic mice had impa...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Yura, Yoshimitsu, Chong, Brian S. H., Johnson, Ryan D., Watanabe, Yosuke, Tsukahara, Yuko, Ferran, Beatriz, Murdoch, Colin E., Behring, Jessica B., McComb, Mark E., Costello, Catherine E., Janssen-Heininger, Yvonne M. W., Cohen, Richard A., Bachschmid, Markus M., Matsui, Reiko
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894059/
https://ncbi.nlm.nih.gov/pubmed/31647879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900786R
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