Inositol polyphosphate multikinase is a metformin target that regulates cell migration

Metformin has been shown to alter cell adhesion protein expression, which is thought to play a role in its observed antitumor properties. We found that metformin treatment down-regulated integrin β1 concomitant with the loss of inositol polyphosphate multikinase (IPMK) in murine myocytes, adipocytes...

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Dades bibliogràfiques
Publicat a:FASEB J
Autors principals: Tu-Sekine, Becky, Padhi, Abinash, Jin, Sunghee, Kalyan, Srivathsan, Singh, Karanpreet, Apperson, Matthew, Kapania, Rakesh, Hur, Soojung Claire, Nain, Amrinder, Kim, Sangwon F.
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894044/
https://ncbi.nlm.nih.gov/pubmed/31657647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900717RR
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