SF2523: Dual PI3K/BRD4 inhibitor blocks tumor immunosuppression and promotes adaptive immune responses in cancer

Macrophages (MΘs) are key immune infiltrates in solid tumors and serve as major drivers behind tumor growth, immune suppression, and inhibition of adaptive immune responses in the tumor microenvironment (TME). Bromodomain and extraterminal (BET) protein, BRD4, which binds to acetylated lysine on his...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Joshi, Shweta, Singh, Alok R., Liu, Kevin X., Pham, Timothy V., Zulcic, Muamera, Skola, Dylan, Chun, Hyun Bae, Glass, Christopher K., Morales, Guillermo A., Garlich, Joseph R., Durden, Donald L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893301/
https://ncbi.nlm.nih.gov/pubmed/31018997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1206
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