Endoplasmic reticulum Ca(2+) release causes Rieske iron–sulfur protein-mediated mitochondrial ROS generation in pulmonary artery smooth muscle cells

Mitochondrial reactive oxygen species (ROS) cause Ca(2+) release from the endoplasmic reticulum (ER) via ryanodine receptors (RyRs) in pulmonary artery smooth muscle cells (PASMCs), playing an essential role in hypoxic pulmonary vasoconstriction (HPV). Here we tested a novel hypothesis that hypoxia-...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Dong, Dapeng, Hao, Qiongyu, Zhang, Ping, Wang, Tao, Han, Fei, Liang, Xiaodong, Fei, Zhenghua
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2019
Assuntos:
Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893167/
https://ncbi.nlm.nih.gov/pubmed/31710081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20192414
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