Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging

Neuroferritinopathy (NF) is a movement disorder caused by alterations in the L-ferritin gene that generate cytosolic free iron. NF is a unique pathophysiological model for determining the direct consequences of cell iron dysregulation. We established lines of induced pluripotent stem cells from fibr...

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Udgivet i:Stem Cell Reports
Main Authors: Cozzi, Anna, Orellana, Daniel I., Santambrogio, Paolo, Rubio, Alicia, Cancellieri, Cinzia, Giannelli, Serena, Ripamonti, Maddalena, Taverna, Stefano, Di Lullo, Giulia, Rovida, Ermanna, Ferrari, Maurizio, Forni, Gian Luca, Fiorillo, Chiara, Broccoli, Vania, Levi, Sonia
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893074/
https://ncbi.nlm.nih.gov/pubmed/31587993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.09.002
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