Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging

Neuroferritinopathy (NF) is a movement disorder caused by alterations in the L-ferritin gene that generate cytosolic free iron. NF is a unique pathophysiological model for determining the direct consequences of cell iron dysregulation. We established lines of induced pluripotent stem cells from fibr...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Cozzi, Anna, Orellana, Daniel I., Santambrogio, Paolo, Rubio, Alicia, Cancellieri, Cinzia, Giannelli, Serena, Ripamonti, Maddalena, Taverna, Stefano, Di Lullo, Giulia, Rovida, Ermanna, Ferrari, Maurizio, Forni, Gian Luca, Fiorillo, Chiara, Broccoli, Vania, Levi, Sonia
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893074/
https://ncbi.nlm.nih.gov/pubmed/31587993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.09.002
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