Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts

Parkinson’s disease (PD) and Multiple System Atrophy (MSA) are clinically distinctive diseases that feature a common neuropathological hallmark of aggregated α-synuclein. Little is known about how differences in α-synuclein aggregate structure affect disease phenotype. Here, we amplified α-synuclein...

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Publicat a:Nat Commun
Autors principals: Strohäker, Timo, Jung, Byung Chul, Liou, Shu-Hao, Fernandez, Claudio O., Riedel, Dietmar, Becker, Stefan, Halliday, Glenda M., Bennati, Marina, Kim, Woojin S., Lee, Seung-Jae, Zweckstetter, Markus
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893031/
https://ncbi.nlm.nih.gov/pubmed/31797870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13564-w
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