Electron Paramagnetic Resonance Spectroscopy Measures the Distance between the External β-Strands of Folded α-Synuclein in Amyloid Fibrils

The misfolding of α-synuclein (αS) to a cross-β-sheet amyloid structure is associated with pathological conditions in Parkinson's and other neurodegenerative diseases. Using pulse electron paramagnetic resonance spectroscopy combined with a cross-labeling strategy involving four double mutants,...

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Detalhes bibliográficos
Main Authors: Karyagina, Irina, Becker, Stefan, Giller, Karin, Riedel, Dietmar, Jovin, Thomas M., Griesinger, Christian, Bennati, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2011
Assuntos:
Biophysical Letter
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127190/
https://ncbi.nlm.nih.gov/pubmed/21723808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.05.052
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