ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation

Women have increased prevalence of Th17-mediated autoimmune diseases, including lupus and multiple sclerosis, and severe asthma. While estradiol and progesterone increased IL-17A production in Th17 cells by inhibiting Let7f miRNA expression and increasing IL-23 receptor (IL-23R) expression, it remai...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Fuseini, Hubaida, Cephus, Jacqueline-Yvonne, Wu, Pingsheng, Davis, J. Brooke, Contreras, Diana C., Gandhi, Vivek D., Rathmell, Jeffrey C., Newcomb, Dawn C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892971/
https://ncbi.nlm.nih.gov/pubmed/31849948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02740
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