Skeletal muscle alterations in tachycardia-induced heart failure are linked to deficient natriuretic peptide signalling and are attenuated by RAS-/NEP-inhibition

BACKGROUND: Heart failure induced cachexia is highly prevalent. Insights into disease progression are lacking. METHODS: Early state of left ventricular dysfunction (ELVD) and symptomatic systolic heart failure (HF) were both induced in rabbits by tachypacing. Tissue of limb muscle (LM) was subjected...

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Опубликовано в: :PLoS One
Главные авторы: Dietl, Alexander, Winkel, Ingrid, Pietrzyk, Gabriela, Paulus, Michael, Bruckmann, Astrid, Schröder, Josef A., Sossalla, Samuel, Luchner, Andreas, Maier, Lars S., Birner, Christoph
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2019
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892497/
https://ncbi.nlm.nih.gov/pubmed/31800630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0225937
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