Effects of Ranolazine on Torsades de Pointes Tachycardias in a Healthy Isolated Rabbit Heart Model

PURPOSE: Torsades de pointes (TdP) tachycardias are triggered, polymorphic ventricular arrhythmias arising from early afterdepolarizations (EADs) and increased dispersion of repolarization. Ranolazine is a new agent which reduces pathologically elevated late I(Na) but also I(Kr). Aim of this study w...

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Detalhes bibliográficos
Publicado no:Cardiovasc Ther
Main Authors: Sossalla, Samuel, Wallisch, Nora, Toischer, Karl, Sohns, Christian, Vollmann, Dirk, Seegers, Joachim, Lüthje, Lars, Maier, Lars S, Zabel, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285941/
https://ncbi.nlm.nih.gov/pubmed/24785406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/1755-5922.12078
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