Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model

Salmonella Typhi is a human host-restricted pathogen that is responsible for typhoid fever in approximately 10.9 million people annually(1). The typhoid toxin is postulated to have a central role in disease pathogenesis, the establishment of chronic infection and human host restriction(2–6). However...

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Veröffentlicht in:Nat Med
Hauptverfasser: Gibani, Malick M., Jones, Elizabeth, Barton, Amber, Jin, Celina, Meek, Juliette, Camara, Susana, Galal, Ushma, Heinz, Eva, Rosenberg-Hasson, Yael, Obermoser, Gerlinde, Jones, Claire, Campbell, Danielle, Black, Charlotte, Thomaides-Brears, Helena, Darlow, Christopher, Dold, Christina, Silva-Reyes, Laura, Blackwell, Luke, Lara-Tejero, Maria, Jiao, Xuyao, Stack, Gabrielle, Blohmke, Christoph J., Hill, Jennifer, Angus, Brian, Dougan, Gordon, Galán, Jorge, Pollard, Andrew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group US 2019
Schlagworte:
Letter
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892374/
https://ncbi.nlm.nih.gov/pubmed/31270506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0505-4
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