Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial

BACKGROUND: Salmonella enterica serovar Typhi (S Typhi) is responsible for an estimated 20 million infections and 200 000 deaths each year in resource poor regions of the world. Capsular Vi-polysaccharide-protein conjugate vaccines (Vi-conjugate vaccines) are immunogenic and can be used from infancy...

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Publicado no:Lancet
Principais autores: Jin, Celina, Gibani, Malick M, Moore, Maria, Juel, Helene B, Jones, Elizabeth, Meiring, James, Harris, Victoria, Gardner, Jonathan, Nebykova, Anna, Kerridge, Simon A, Hill, Jennifer, Thomaides-Brears, Helena, Blohmke, Christoph J, Yu, Ly-Mee, Angus, Brian, Pollard, Andrew J
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720597/
https://ncbi.nlm.nih.gov/pubmed/28965718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(17)32149-9
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