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The role of WNK in modulation of KCl cotransport activity in red cells from normal individuals and patients with sickle cell anaemia
Abnormal activity of red cell KCl cotransport (KCC) is involved in pathogenesis of sickle cell anaemia (SCA). KCC-mediated solute loss causes shrinkage, concentrates HbS, and promotes HbS polymerisation. Red cell KCC also responds to various stimuli including pH, volume, urea, and oxygen tension, an...
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| Publicado no: | Pflugers Arch |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6892352/ https://ncbi.nlm.nih.gov/pubmed/31729557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-019-02327-7 |
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